Table 4.
Cox regression analysis of LVDD (E/e′ > 14) for the risk of cardiovascular (CV) events in various subgroups.
| Events, n (%) | Unadjusted | Adjusted | |||
|---|---|---|---|---|---|
| HR (95%CIs) | P for interaction | HR (95%CIs) | P for interaction | ||
| Age < 60 years | 71 (5.1) | 3.829 (2.437,6.015) | 0.511 | 2.988 (1.843,4.846) | 0.308 |
| Age ≥ 60 years | 100 (13.4) | 2.024 (1.044,3.925) | 1.020 (0.484,2.151) | ||
| Male | 123 (9.4) | 3.541 (2.287,5.483) | 0.475 | 2.373 (1.487,3.787) | 0.295 |
| Female | 48 (5.8) | 2.314 (1.137,4.708) | 1.856 (0.851,4.046) | ||
| Charlson comorbidity index ≤ 3 | 82 (5.4) | 3.015 (1.925,4.723) | 0.624 | 2.253 (1.408,3.603) | 0.341 |
| Charlson comorbidity index ≥ 4 | 89 (14.5) | 3.211 (1.662,6.203) | 2.621 (1.262,5.443) | ||
| BMI < 23 kg/m2 | 48 (7.1) | 2.518 (0.329,19.269) | 0.886 | 2.097 (0.209,21.081) | 0.738 |
| BMI ≥ 23 kg/m2 | 123 (8.5) | 2.366 (1.619,3.458) | 2.184 (1.465,3.256) | ||
| eGFR ≥ 45 ml/min/1.73m2 | 66 (6.4) | 3.581 (2.146,5.975) | 0.984 | 3.051 (1.758,5.295) | 0.588 |
| eGFR < 45 ml/min/1.73m2 | 105 (9.5) | 2.538 (1.473,4.373) | 1.827 (1.007,3.313) | ||
| Spot urine ACR < 300 mg/gCr | 70 (7.3) | 3.984 (2.368,6.703) | 0.364 | 3.223 (1.822,5.700) | 0.178 |
| Spot urine ACR ≥ 300 mg/gCr | 94 (8.6) | 2.414 (1.417,4.111) | 1.767 (0.991,3.150) | ||
Models were adjusted for age, sex, Charlson comorbidity index, smoking history, medication (ACEi/ARBs, diuretics, number of antihypertensive drugs, statins), BMI, SBP, DBP, hemoglobin, albumin, fasting serum glucose, HDL-C, TG, 25(OH) vitamin D, hs-CRP, GFR, spot urine ACR, and EF at the baseline. ACR, albumin-to-creatinine ratio; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio.