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. 2022 Mar 25;12:868905. doi: 10.3389/fcimb.2022.868905

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Copyright © 2022 Krzyżek, Migdał, Grande and Gościniak

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between the biofilm formation capacity of 24 clinical H. pylori strains and their resistance profile (A) or resistance to a specific type of antibiotic (B). Determination of biofilm production was performed in static conditions and a 3-day incubation using a crystal violet staining method. The correlation between the biofilm formation and resistance profile (A) was calculated by the Kruskal Wallis test and columns with the same subscript letters (a, b, c) are not significantly different from each other (p > 0.05). The correlation between the biofilm formation and resistance to a specific type of antibiotic (B) was calculated by the Spearman correlation test, where 0 means no dependence and 1 a very strong dependence. The tests were performed in three biological replications with six technical repetitions (n = 18/strain). CLR, clarithromycin; MTZ, metronidazole; LEV, levofloxacin.