Activity of 5 mg of tucaresol per kg against L. donovani infections in livers (■) and spleens (●) of BALB/c mice. Groups of mice were separately treated during either week 1, 2, 3, 4, 5, 6, 7, or 8 of infection and were killed 3 days after the completion of dosing. Data represent means ± SEMs derived from five mice per time point.