TABLE 1.
The history of the discovery of pyroptosis and its related research developments.
| Year | Stimulators | Pathway | Results | References |
|---|---|---|---|---|
| 1992 | Shigella flexneri | — | Apoptosis in infected macrophages | Zychlinsky et al. (1992) |
| 1997 | Shigella dysenteriae | Activate caspase-1 in host cells | Hilbi et al. (1997) | |
| 1999 | Salmonella | Caspase-1 | The cell death | Hersh et al. (1999) |
| 2001 | — | — | A programmed cell death occurs through caspase-1 dependent mechanism | Boise and Collins (2001) |
| 2015 | Caspases 1/4/5/11 | GSDMD | Pyroptotic cell death | Shi et al. (2015) |
| 2017 | Chemotherapy drug | Caspase-3/GSDME | apoptosis | Wang et al. (2017) |
| 2018 | Caspase-8 | GSDMD | Pyroptosis | Sarhan et al. (2018) |
| 2020 | GSDME | CAR T cell | Cytokine release syndrome | Liu Y et al. (2020) |
| 2020 | GAZA | GSDMB | Pyroptosis | Zhou et al. (2020) |
| 2020 | Caspase-8 | GSDMC | Pyroptosis in cancer cells | Hou et al. (2020) |