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. 2022 Mar 25;14:848991. doi: 10.3389/fnagi.2022.848991

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Copyright © 2022 Cazzaniga, Bistaffa, De Luca, Portaleone, Catania, Redaelli, Tramacere, Bufano, Rossi, Caroppo, Giovagnoli, Tiraboschi, Di Fede, Eleopra, Devigili, Elia, Cilia, Fiorini, Bongianni, Salzano, Celauro, Quarta, Mammana, Legname, Tagliavini, Parchi, Zanusso, Giaccone and Moda.

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Analysis of olfactory mucosa samples by PMCA. (A) PrP^res detection in OM of 10/14 MM samples (including 4 MM1, 1 E200K and 5 MMunk), 8/9 MV samples (including 5 MV2, 1 E200K and 2 MVunk) and 5/6 VV samples (including 3 VV2 and 2 VVunk). Samples with known PrP^res typing are written in bold. No PrP^res was found in the OM of patients with OND (AD: OND1, OND4 and OND6; Parkinson’s disease: OND2; Corticobasal degeneration: OND3 and OND5). Numbers in the right of each Wb indicate the molecular weight marker. (B) Schematic representation of the PMCA rounds at which PrP^res was detected in each OM sample. Black and white boxes indicate the presence or absence of PrP^res, respectively. (C) Radar plots showing the PrP^res predominant species of OM_PMCA samples. Numerical scale in each radar plot indicates the mean density of the PrP^res isoform.