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. 2022 Mar 25;14:848991. doi: 10.3389/fnagi.2022.848991

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Copyright © 2022 Cazzaniga, Bistaffa, De Luca, Portaleone, Catania, Redaelli, Tramacere, Bufano, Rossi, Caroppo, Giovagnoli, Tiraboschi, Di Fede, Eleopra, Devigili, Elia, Cilia, Fiorini, Bongianni, Salzano, Celauro, Quarta, Mammana, Legname, Tagliavini, Parchi, Zanusso, Giaccone and Moda.

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PK resistance analysis of BH and their amplified products collected at the 6^th PMCA round. (A) PK resistant profiles of all sCJD brain amplified products (BH_PMCA) did not show statistically significant differences. (B) PK resistant profiles of all sCJD OM amplified products (OM_PMCA) did not show statistically significant differences. (C) PK resistant profiles of BH, BH_PMCA and OM_PMCA of MM1 patients showing statistically significant differences only between BH and BH_PMCA or BH and OM_PMCA. (D) PK resistant profiles of BH, BH_PMCA and OM_PMCA of MV2 patients showing statistically significant differences only between BH and OM_PMCA. (E) PK resistant profiles of BH, BH_PMCA and OM_PMCA of VV2 patients showing statistically significant differences between BH, BH_PMCA and OM_PMCA. Statistical analyses: repeated measure analysis of variance (ANOVA); BH vs. BH_PMCA: *p < 0.05, **p < 0.01, ***p < 0.001, BH vs. OM_PMCA: °°p < 0.01, °°°p < 0.001 and BH_PMCA vs. OM_PMCA ^◆◆◆p < 0.001; error bars: ± standard error of the mean [SEM].