TABLE 4.
Antimicrobial susceptibilities of clinical isolates and E. coli transformants producing TEM-47 and TEM-68
| Strain (ESBL type) | MIC (μg/ml)
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMPa | PIP | PIP-TAZ | CTX | CTX-CLAV | CAZ | CAZ-CLAV | ATM | ATM-CLAV | FOX | IPM | AK | GN | |
| K. pneumoniae 3144/98 (TEM-47) | >512 | >512 | 2 | 8 | ≤0.03 | 128 | 0.25 | 128 | 0.125 | 4 | 0.125 | 1 | 32 |
| K. pneumoniae 3151/98 (TEM-68) | >512 | >512 | >512 | 32 | 8 | 256 | 128 | 256 | 64 | 32 | 0.25 | 2 | 128 |
| E. coli DH5α/pGBT-47 (TEM-47) | >512 | 256 | 1 | 8 | ≤0.03 | 64 | 0.25 | 64 | 0.125 | 8 | 0.125 | 0.5 | 0.25 |
| E. coli DH5α/pGBT-68 (TEM-68) | >512 | 256 | 1 | 8 | ≤0.03 | 64 | 0.25 | 64 | 0.125 | 8 | 0.125 | 0.5 | 0.25 |
| E. coli DH5α | 2 | ≤0.5 | 1 | 0.06 | ≤0.03 | 0.25 | 0.125 | 0.06 | 0.125 | 8 | 0.125 | 0.5 | 0.25 |
a
AMP, ampicillin; PIP, piperacillin; CTX, cefotaxime; CAZ, ceftazidime; ATM, aztreonam; FOX, cefoxitin; IPM, imipenem; TAZ, tazobactam (4 μg/ml); CLAV, clavulanate (2 μg/ml); AK, amikacin; GN, gentamicin.