TABLE 5.
MICs of piperacillin combined with various concentrations of clavulanate and tazobactam for TEM-47- and TEM-68-producing klebsiella clinical isolates and E. coli transformants
| Strain (ESBL type) | MIC (μg/ml) of piperacillin–clavulanate/tazobactam at inhibitor concn (μg/ml) of:
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 0.0075 | 0.015 | 0.03 | 0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | |
| K. pneumoniae 3144 (TEM-47) | >512/>512 | 512/—a | 256/— | 64/— | 16/— | 8/— | 4/— | 4/256 | 4/4 | 4/2 | 2/2 |
| K. pneumoniae 3151 (TEM-68) | >512/>512 | >512/— | >512/— | >512/— | >512/— | >512/— | >512/— | >512/>512 | >512/>512 | 512/>512 | 8/>512 |
| E. coli DH5α/pGBT-47 (TEM-47) | 256/256 | 64/— | 32/— | 4/— | 2/— | 1/— | 1/— | 1/2 | 1/1 | 1/1 | 0.5/1 |
| E. coli DH5α/pGBT-68 (TEM-68) | 256/256 | 128/— | 128/— | 32/— | 4/— | 2/— | 1/— | 1/128 | 1/64 | 1/2 | 0.5/1 |
| E. coli DH5α | 0.5/1 | 0.5/— | 0.5/— | 0.5/— | 0.5/— | 0.5/— | 0.5/— | 0.5/1 | 0.5/1 | 0.5/1 | 0.5/1 |
| E. coli ATCC 25922 | 2/2 | 2/— | 2/— | 2/— | 2/— | 2/— | 2/— | 2/2 | 2/2 | 2/2 | 2/2 |
a
—, not determined.