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. 2022 Mar 25;13:691829. doi: 10.3389/fphys.2022.691829

FIGURE 1.

FIGURE 1

Effect of catecholaminergic polymorphic ventricular tachycardia (CPVT) alleles and fkb-2 deletion on pharyngeal muscle cells (PMCs) and body-wall muscles (BWMs). (A) Unc-68(S2378L) shows a reduced normalized pump rate compared to the respective wild type (wt) control strain (young adult animals). (B) Deletion of fkb-2 [fkb-2(ok3007)] has no/minor effect on spontaneous pump rate on food. (C) Alleles R414Q and Q4623R show a reduction of normalized swimming cycles. (D) No significant effect of fkb-2 deletion on numbers of swimming cycles in comparison to the respective wild-type control. Whereas fkb-2 deletion in the pmyo-2::ChR2 background shows an increased number of swimming cycles in comparison to pmyo-2::ChR2. Bar graphs display mean values ± SEM. One-way ANOVA with the Bonferroni post-hoc test (B,D) or two-sample t-test for the comparison of only two mean values (A,C): *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001.