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. 2022 Apr 7;5(4):e225403. doi: 10.1001/jamanetworkopen.2022.5403

Table 2. Modeling Performance Metrics.

Modela AUC, mean (95% CI) Cut point Sensitivity Specificity PPV, % NPV, % BAC PSI
Conv-LSTM model
Held-out test set (activity only) 0.66 (0.64-0.68) 0.48 0.79 0.50 5.77 98.43 0.65 10.02
Cross-validation sets (activity only) 0.67 (0.64-0.71) 0.49 0.68 0.60 6.90 98.10 0.64 10.03
Conv-LSTM model with depression scores
Held-out test set (PHQ-9 plus activity) 0.66 (0.65-0.67) 0.50 0.74 0.56 6.13 98.26 0.65 10.10
Cross-validation sets (PHQ-9 plus activity) 0.70 (0.65-0.75) 0.50 0.73 0.60 7.10 98.35 0.66 10.20
Wavelet LogReg model
Held-out test set 0.64 (0.64-0.64) 0.08 0.72 0.56 5.95 98.15 0.64 3.40
Cross-validation sets 0.65 (0.60-0.71) 0.06 0.72 0.54 6.05 98.22 0.63 3.41

Abbreviations: AUC, area under the receiver operating characteristic curve; BAC, balanced accuracy; Conv-LSTM, convolutional–long short-term memory; LogReg, logistic regression; NPV, negative predictive value; PHQ-9, 9-item Patient Health Questionnaire; PPV, positive predictive value; PSI, population stability index.

a

Given the small size of our selective serotonin reuptake inhibitor group, we present these metrics for each model (Conv-LSTM run with movement data alone, Conv-LSTM run with movement data and depression scores, and logistic regression operating on wavelet-derived features) to ensure comprehensive report of model performance. Sensitivity, specificity, PPV, NPV, BAC, and PSI are mean values across 10 cross-validation sets or across distinct model runs of held-out test set; AUC remains the primary outcome metric, which is discussed in the Results and Discussion sections.