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Toxicity of methylenecyclopropane analogues in HFF or MEF
| Drug | CC50 (μM) for neutral red uptake in:
|
IC50 (μM) for cell proliferation in HFF | |
|---|---|---|---|
| HFF | MEF | ||
| GCV | >392 | >39.2 | 157 |
| ACV | >392 | NTa | >392 |
| QYL-284A | >460 | >460 | 164 |
| QYL-438 | >429 | >429 | 278 |
| QYL-468 | >518 | >518 | 356 |
| QYL-546 | >431 | >293 | 426 |
| QYL-587A | >460 | >518 | 247 |
| QYL-678 | >206 | >206 | 206 |
| QYL-685 | 121 | 211 | 211 |
| QYL-769 | 327 | 220 | 255 |
| QYL-418 | 185 | 260 | 158 |
| QYL-788 | 180 | 296 | 67.7 |
| QYL-972 | 34.1 | 126 | 2.4 |
| QYL-941 | >404 | 260 | 243 |
| QYL-975 | 126 | 101 | 2.7 |
NT, not tested.
