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. 2022 Mar 28;13(6):1923–1932. doi: 10.7150/jca.66914

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Hdac11 is downregulated and Mmp3 is upregulated in chemically-induced CAC mouse model. (A) The expressions of Hdac11 and Mmp3 in mouse colitis tissue, CAC tissue, and normal colon tissue was evaluated with qRT-PCR analysis. (B) Representative images of Hdac11 and Mmp3 expression in CAC mouse model using immunohistochemistry. Left panel indicates mouse normal colon tissue, middle panel indicates colitis tissue and right panel indicates adenocarcinoma tissue. (C) Kinetics of LPS-induced Hdac11 and Mmp3 expression in murine macrophages RAW264.7 cells. Error bars represent SD. *p < 0.05, **p < 0.01, ***p < 0.001 compared with control.