Table 3.
Univariable and Multivariable Logistic Regression for associations between Risk Factors and Early Recurrence of CRLM after Resection (<11 mo)
| Factor | Unitivariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| P | OR (95%CI) | P | OR (95%CI) | |
| Demographics and clinicopathological features | ||||
| Age ≥60 years | 0.756 | 1.133(0.514-2.499) | ||
| Male | 0.410 | 0.729(0.343-1.548) | ||
| BMI≥24kg/m2 | 0.128 | 1.774(0.849-3.707) | ||
| Comorbidity | 0.933 | 1.032(0.494-2.157) | ||
| ASA score 3-4 | 0.220 | 2.242(0.616-8.159) | ||
| Primary site in colon | 0.820 | 0.918(0.442-1.910) | ||
| Right hemicolon | 0.062 | 7.091(0.908-55.367) | NS | NS |
| Poor differentiation | 0.444 | 1.396(0.594-3.283) | ||
| T3-T4 stage | 0.962 | 1.042(0.194-5.602) | ||
| Primary lymph node metastasis | 0.496 | 1.336(0.580-3.077) | ||
| Synchronous liver metastasis | 0.030 | 3.065(1.117-8.405) | 0.028 | 3.416(1.139-10.251) |
| Diameter of largest liver metastases ≥ 3 cm | 0.168 | 1.684(0.803-3.531) | ||
| Multiple liver metastases | 0.067 | 2.128(0.950-4.770) | NS | NS |
| Bilobar liver distribution | 0.094 | 1.878(0.899-3.923) | NS | NS |
| Extrahepatic metastases | 0.575 | 0.739(0.257-2.125) | ||
| Preoperative laboratory testing levels | ||||
| Preoperative CEA ≥10 ng/ml | 0.269 | 1.531(0.719-3.261) | ||
| Preoperative GGT ≥ 38 U/L | 0.635 | 1.194(0.575-2.477) | ||
| Preoperative D-dimer ≥0.48 mg/L | 0.224 | 1.578(0.756-3.295) | ||
| Preoperative ALT ≥ 20.5 U/L | 0.710 | 0.871(0.420-1.807) | ||
| Preoperative AST ≥ 24 U/L | 0.420 | 0.739(0.354-1.542) | ||
| Preoperative ALB ≥ 41.8 g/L | 0.710 | 0.871(0.420-1.807) | ||
| Preoperative FIB ≥ 3.15 g/L | 0.710 | 0.871(0.420-1.807) | ||
| Preoperative LDH ≥ 177.5 U/L | 0.710 | 0.871(0.420-1.807) | ||
| Preoperative creatinine ≥ 63.5 μmol/L | 0.035 | 2.252(1.058-4.796) | 0.043 | 2.362(1.027-5.435) |
| Surgery and chemotherapy details | ||||
| Heterochronous resection | 0.712 | 0.860(0.385-1.919) | ||
| R0 resection | 0.044 | 0.443(0.200-0.979) | NS | NS |
| Major liver resection | 0.954 | 0.971(0.351-2.687) | ||
| Concomitant RFA | 0.072 | 2.579(0.919-7.241) | NS | NS |
| Operation time ≥ 346.5 min | 0.710 | 1.149(0.554-2.383) | ||
| Blood loss ≥ 300 ml | 0.229 | 1.568(0.753-3.264) | ||
| Postoperative complications | 0.009 | 2.741(1.284-5.854) | 0.006 | 3.261(1.399-7.599) |
| Oxaliplatin based NAC regimen | 0.132 | 0.533(0.235-1.208) | ||
| NAC cycles ≥ 4 | 0.003 | 3.560(1.534-8.263) | 0.004 | 3.858(1.548-9.612) |
| Preoperative targeted therapy | 0.251 | 1.581(0.723-3.453) | ||
| Second-line NAC | 0.198 | 1.988(0.699-5.653) | ||
| NAC toxicities | 0.678 | 0.778(0.238-2.544) | ||
| Pathological response | 0.664 | 0.845(0.396-1.805) | ||
| Postoperative chemotherapy | 0.553 | 0.795(0.372-1.697) | ||
NS, not significant.