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. 2022 Mar 28;13(6):1933–1944. doi: 10.7150/jca.69338

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Induction of Apoptosis by ONP-302. LLC tumor bearing C57BL/6 mice were intravenously injected with fluorescently labeled (Alexa-Fluor 647) ONP-302 50mg/kg. for 2 weeks. 2 hours after last treatment, mice were sacrificed, and single-cell suspensions were prepared from the tumor and spleen. Induction of Apoptosis by ONP-302 was analyzed by flow cytometry. A. Flow cytometry gating scheme for identifying apoptotic TAMs (CD11b+F4/80+), M-MDSC (CD11b+ Ly6Chi Ly6G-), and PMN-MDSC (CD11b+ Ly6C- Ly6G+) and CAFs (CD45-CD140a+CD326-) using the indicated cell-surface markers. B. Flow cytometry analysis of indicated apoptotic cells in tumor.