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TDG interacts with DNMT3A. (A-B) The expression of DNMT3A was detected by qRT-PCR and western blotting after transfected with TDG plasmid. (C-D) Co-IP was applied to vivificate the combination of TDG and DNMT3A. (E) CHX promoted the degradation rate of DNMT3A. (F) MG132 inhibited the decrease of DNMT3A caused by TDG. (G) TDG increased the ubiquitination level of DNMT3A. *P<0.05, **P<0.01, ***P<0.001.
