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. 2022 Mar 14;18(6):2419–2438. doi: 10.7150/ijbs.67200

Figure 8.

Figure 8

Mutant p53 increases tumor growth and PD-L1 expression in colorectal cancer patients. (A) To study the expression of p53 and PD-L1 or AKT in patients, lysates from tissues by immunoblotted with indicated antibodies were analyzed in colorectal cancer patients. (B) Schematic representation of missense mutant p53 related immune therapy signaling pathway. (C) Representative images depicting immunohistochemical (IHC) staining of p53, PD-L1, Ki67, CD8a, and F4/80 of p53 missense mutation and wild-type in colorectal tissues.