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. 2022 Mar 6;18(6):2235–2248. doi: 10.7150/ijbs.64943

Figure 2.

Figure 2

Effect of ALKBH5 on myeloma cell proliferation, apoptosis, angiogenesis, migration, and invasion in vitro. (A) and (B) The proliferation and viability of ALKBH5- RPMI8226, ALKBH5- NCI-H929, ALKBH5+ RPMI8226, ALKBH5+ ARH77 cells and control cells were assessed by CCK-8 assays. Annexin V-PE/7AAD staining was performed to examine apoptosis rate of the ALKBH5+ and ALKBH5- RPMI8226 cells(C) and NCI-H929 cells(D), (E) and (F) The invasion and migration abilities of ALKBH5- and ALKBH5+ RPMI8226 myeloma cells were assessed by transwell assays.(G) The VEGF levels of ALKBH5- and ALKBH5+ RPMI8226 myeloma cells were assessed by ELISA. Data are expressed as the mean ± SEM of each group from three separate experiments. ***P<0.001, ****P<0.0001.