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ALKBH5 deficiency repressed the growth of MM cells in vivo. (A) Tumour growth curves for the mice injected with ALKBH5- and control RPMI8226 cells. (B) Images of the tumour sections from the NOD/SCID mouse xenograft models (ALKBH5- : n=5, Control: n=5). (C) Representative immunohistochemical staining for ALKBH5, YAP, SAV1, Ki67, BAX, BCL-2, Pakt and caspase3 in the tumour tissues derived from mice injected with ALKBH5- and control RPMI8226 cells. Bar=50μm. ****P<0.0001.
