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. 2022 Mar 6;18(6):2235–2248. doi: 10.7150/ijbs.64943

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Features of the m⁶A methylome and mRNA level changes in ALKBH5^- and control RPMI8226 cells. (A) Relative m⁶A content of the RNA in the ALKBH5^-, control RPMI8226 cells and the NCs. (B) Charts of the m6A peak distribution indicating the proportion of peaks in different regions of the ALKBH5^- and control RPMI8226 cells. (C) The m⁶A consensus motif in ALKBH5^- and control RPMI8226 cells was analysed by HOMER. (D) m⁶A peak counts representing the ALKBH5^- and control RPMI8226 cells were identified by MeRIP-seq. (E) The measurement of genes that changed in a m⁶A manner in ALKBH5^-, control RPMI8226 cells and CD138⁺ cells from healthy volunteers (NCs). 24 genes were downregulated in 1649 ALKBH5^--specific genes and 120 genes were downregulated in NC-specific genes. (F) Tracks of m⁶A modifications of SAV1 mRNA in the ALKBH5^- and control RPMI8226 cells.