TABLE 3.
Mean drug levels in CSF and serum measured between 17 and 26 h postdosing by bioassay
| Drug | Body fluid | Mean ± SD drug concn (μg/ml) on the following days postinfection (no. of doses):
|
|||
|---|---|---|---|---|---|
| 11–12 (6 or 7) | 20–21 (15 or 16) | 32–33 (27 or 28) | 39–40a | ||
| FCZ | Serum | 40.0 ± 7.17 (8)b | 31.9 ± 7.88 (8) | 28.1 ± 9.48 (8) | 0 (8) |
| CSF | 29.9 ± 7.12 (8) | 25.8 ± 4.98 (8) | 22.4 ± 9.68 (8) | 0 (8) | |
| ITZ | Serum | 2.51 ± 1.02 (6) | 2.22 ± 1.22 (7) | 0.77 ± 0.42 (7) | 0 (7) |
| CSF | 0 (7) | 0 (6) | 0 (6) | 0 (7) | |
a
After a 7- or 8-day washout period.
b
Values in parentheses in table body are number of rabbits.