. 2022 Apr 8;33(5):1619–1643. doi: 10.1007/s11224-022-01932-0

Table 1.

List of antiviral compounds of the endophytes with their metadata

Sr. no	Secondary metabolite	Endophytic organism	Host	Location	Virus	Activity (IC₅₀)	Reference
1	6-O-Demethyl-4-dehydroxyaltersolanol A	Nigrospora sp. YE3033	Aconitum carmichaelii	China	H1N1 influenza A	2.59 ± 1.22 µg/mL	[61]
2	4-Dehydroxyaltersolanol A					8.35 ± 1.41 µg/mL
3	Altersolanol B					7.82 ± 1.86 µg/mL
4	Chermesinone B					0.80 ± 0.29 µg/mL
5	Emodin	Aspergillus versicolor	Halimeda opuntia	Egypt	HCV protease	22.5 ± 1.6 µg/mL	[20]
6	ω-Hydroxyemodin	Fusarium equiseti	Padina pavonica	Egypt	HCV protease	10.71 ± 2.3 µM	[22]
7	( +)-Sclerotiorin	Penicillium sclerotiorum PSU-A13	Garcinia atroviridis	Thailand	HIV-1 integrase	14.5 µg/mL	[23]
7	( +)-Sclerotiorin	Penicillium sclerotiorum PSU-A13	Garcinia atroviridis	Thailand	HIV-1 protease	62.7 µg/mL	[23]
8	Cordycepin	Fusarium equiseti	Padina pavonica	Egypt	HCV protease	22.3 µM	[22]
9	Ara-A					24.5 µM
10	Cyclic tetrapeptidecyclo-[phenyl alanyl-pro-leu-pro]					29.4 µM
11	17-Demethyl-2,11-dideoxy-rhizoxin					29.4 µM
12	5-Chloro-3,6-dihydroxy-2-methyl-1,4-benzoquinone					34.4 µM
13	Perlolyrine					35.1 µM
14	Cyclo (l-Pro-l-Val)					23.2 µM
15	Griseoxanthone C					19.8 µM
16	Stachybogrisephenone B	Stachybotry sp. HH1 ZDDS1F1-2	Sponge	China	EV71	30.1 µM	[62]
17	Grisephenone A					50.0 µM
18	3,6,8-Trihydroxy-1-methylxanthine					40.3 µM
19	Emerimidine A	Emericella sp. (HK-ZJ)	Aegiceras corniculatum	China	H1N1 influenza A	42.07 µg/mL	[63]
20	Emerimidine B	Emericella sp. (HK-ZJ)	Aegiceras corniculatum	China	H1N1 influenza A	62.05 µg/mL	[63]
21	Chloropupukeananin	Pestalotiopsis fici	Unknown	China	HIV-1	14.6 µM	[64]
22	Periconiasin G	Periconia sp. F-31	Annona muricata	China	HIV-1	67.0 µM	[65]
23	Aspergilline A	Aspergillus versicolor	Paris polyphylla var. yunnanensis	China	Tobacco mosaic virus	56.4 ± 3.8 μM	[60]
24	Aspergilline B					47.3 ± 3.2 μM
25	Aspergilline C					35.6 ± 2.8 μM
26	Aspergilline D					38.9 ± 3.5 μM
27	Aspergilline E					33.6 ± 3.0 μM
28	Cytonic acid A	Cytonaema sp. F32027	Quercus sp.	UK	CMV protease	43 μM	[58]
29	Cytonic acid B	Cytonaema sp. F32027	Quercus sp.	UK	CMV protease	11 μM	[58]
30	Phomopsone B	Phomopsis sp. CGMCC No.5416	Achyranthes bidentata	China	HIV-1	7.6 μM	[21]
31	Phomopsone C	Phomopsis sp. CGMCC No.5416	Achyranthes bidentata	China	HIV-1	0.5 μM	[21]
32	Altertoxin V	Alternaria tenuissima QUE1Se	Quercus emoryi	USA	HIV-1	0.09 μM	[66]
33	Altertoxin I					1.42 μM
34	Altertoxin II					0.21 μM
35	Altertoxin III					0.29 μM
36	Xiamycin	Streptomyces sp. GT2002/1503	Bruguiera gymnorrhiza	Germany	HIV-1	NA	[67]
37	Xiamycin methyl ester	Streptomyces sp. GT2002/1503	Bruguiera gymnorrhiza	Germany	HIV-1	NA	[67]
38	Neosartoryadin A	Neosartorya udagawae HDN13-313	Avicennia marina	China	H1N1 influenza A	66 μM	[68]
39	Neosartoryadin B	Neosartorya udagawae HDN13-313	Avicennia marina	China	H1N1 influenza A	58 μM	[68]
40	Asperphenalenone A	Aspergillus sp. CPCC 400,735	Kadsura longipedunculata	China	HIV-1	4.5 μM	[59]
41	Asperphenalenone D					2.4 μM
42	Cytochalasin Z8					9.2 μM
43	Epicocconigrone A					6.6 μM
44	Alternariol 5-o-methyl ether	Colletotrichum sp.	NA	China	HIV-1	NA	[69]
45	8-Methyl emodin	Aspergillus versicolor	Halimeda opuntia	Egypt	HCV protease	40.2 ± 2.3 µg/mL	[20]

NA not available