TABLE 1.

Susceptibility of working virus stocks to PCV and ACV measured by the PRA in MRC-5 cells

Virus type	Strain	Resistance to druga:
		PCV			ACV
		IC50 ± SD	Range	n	IC50 ± SD	Range	n
HSV-1	SC16	0.33 ± 0.03	0.28–0.39	12	0.19 ± 0.06	0.10–0.26	12
HSV-1	484	0.36 ± 0.08	0.25–0.52	10	0.20 ± 0.03	0.16–0.25	10
HSV-1	1123	0.30 ± 0.06	0.21–0.38	10	0.17 ± 0.03	0.13–0.21	10
HSV-1	1761	0.22 ± 0.02	0.18–0.25	10	0.14 ± 0.03	0.10–0.20	10
HSV-1	424	0.29 ± 0.03	0.25–0.34	10	0.16 ± 0.02	0.14–0.20	10
HSV-2	SB5	0.65 ± 0.09	0.57–0.83	34	0.52 ± 0.06	0.44–0.60	34
HSV-2	333	0.73 ± 0.15	0.43–1.0	12	0.47 ± 0.06	0.38–0.66	12
HSV-2	6757	0.82 ± 0.12	0.70–1.0	20	0.49 ± 0.06	0.40–0.58	20
HSV-2	6653	0.81 ± 0.17	0.66–1.1	10	0.55 ± 0.05	0.47–0.64	10
HSV-2	64C	0.51 ± 0.03	0.47–0.55	10	0.32 ± 0.04	0.30–0.38	10
HSV-2	83D	0.66 ± 0.04	0.60–0.73	10	0.33 ± 0.03	0.29–0.38	10

^aIC₅₀s and ranges of IC₅₀s are expressed as micrograms per milliliter. n = total number of replicate wells from two independent experiments, except for viruses HSV-2 SB5 and 6757, which represent data from four independent experiments.