FIGURE 1.

Differential infiltration and prognostic significance of CAFs in HPV⁺ and HPV⁻ HNSCC. A, Representative immunohistochemistry (IHC) images of αSMA⁺ CAFs in HPV⁺ and HPV⁻ HNSCC (n = 71). B, Quantitative analysis of IHC scores of αSMA⁺ CAFs in HNSCC with HPV status (n = 71). C, D, Survival analysis of αSMA⁺ CAFs and HPV in 71 HNSCC patients. E, Average fractions of various cells in HPV^+/− HNSCC in TCGA data sets evaluated by EPIC. F, Infiltration ratio of CAFs in HPV^+/− HNSCC in TCGA data sets evaluated by EPIC. G, Infiltration score of CAFs in HPV^+/− HNSCC in TCGA data sets evaluated by MCPcount. H, Infiltration ratio of CAFs in HPV^+/− HNSCC in GSE74927 evaluated by EPIC. I, Infiltration score of CAFs in HPV^+/− HNSCC in GSE74927 evaluated by MCP count. J, Survival analysis of CAFs evaluated by EPIC in HPV⁺ HNSCC in TCGA data sets. K, L, Differential expression of ACTA2 analyzed by DEseq2 in HPV^+/− HNSCC in TCGA data sets and GSE74927. *P < .05; ***P < .001; ****P < .0001