TABLE 2.
Impact of alcohol intake on pancreatic cancer risk and assessment of variant‐drinking interaction
| Analysis | HERPACC‐2 (2001‐2005) | HERPACC‐3 (2005‐2013) | Pooled analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR a | 95% CI | P value | OR a | 95% CI | P value | OR a | 95% CI | P value | ||||
| Alcohol intake (g/d) | ||||||||||||
| 0 | ref | ref | ref | |||||||||
| <23 | 1.16 | 0.73 | 1.86 | 0.532 | 0.81 | 0.54 | 1.22 | 0.321 | 0.99 | 0.73 | 1.34 | 0.953 |
| <46 | 1.27 | 0.67 | 2.39 | 0.460 | 1.22 | 0.69 | 2.15 | 0.502 | 1.26 | 0.83 | 1.90 | 0.283 |
| ≥46 | 1.34 | 0.65 | 2.77 | 0.433 | 1.75 | 0.97 | 3.17 | 0.065 | 1.57 | 1.00 | 2.46 | 0.050 |
| Trend (per 10 g/d) | 1.05 | 0.99 | 1.12 | 0.074 | 1.06 | 1.00 | 1.12 | 0.042 | 1.05 | 1.01 | 1.10 | 0.011 |
| Interaction analyses b | ||||||||||||
| Additive interaction | 0.067 | −0.076 | 0.209 | 0.360 | 0.046 | −0.088 | 0.179 | 0.501 | 0.068 | −0.027 | 0.164 | 0.161 |
| Multiplicative interaction | 1.06 | 0.93 | 1.20 | 0.406 | 1.03 | 0.92 | 1.16 | 0.577 | 1.06 | 0.97 | 1.15 | 0.196 |
Estimates in bold show statistical significance (P < .05).
Abbreviations: ALDH2, aldehyde dehydrogenase 2; CI, confidence interval; HERPACC, Hospital‐based Epidemiologic Research Program at Aichi Cancer Center; OR, odds ratio.
ORs were calculated by a conditional logistic regression model adjusted for age, pack‐years, body mass index, meat intake, processed meat intake, family history of pancreatic cancer, history of diabetes, and ALDH2 rs671 genotype.
Multiplicative interaction was assessed using a Wald test of the coefficient of the interaction term corresponding to a one‐allele change in the genetic variant multiplied by a 10‐g change in daily alcohol intake; the test for additive interaction was carried out using the relative excess risk due to interaction.