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. 2022 Mar 25;13:851556. doi: 10.3389/fimmu.2022.851556

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Copyright © 2022 Spiteri, Ni, Ling, Macia, Campbell, Hofer and King

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increasing numbers of microglia are required to reduce viral load late in WNV-infection. (A) Table showing experimental groups. (B, C) PFU of WNV in brains of PLX and Ctrl mice at dpi 5 (B) and 7 (C). (D, E) Expression of Wnv as determined by qPCR in brains of infected Ctrl and PLX mice at dpi 5 (D) and 7 (E) and PLX-Ctrl at dpi 7 (E). Wnv was normalized to the housekeeping gene, Rpl13a. (F) Correlation analysis between the expression of Wnv and the number of microglia in PLX mice at dpi 7. Data is presented as mean ± SEM from one (plaque assay) or two (qPCR data) independent experiments with at least three mice per group.