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. 2022 Mar 25;13:851556. doi: 10.3389/fimmu.2022.851556

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Copyright © 2022 Spiteri, Ni, Ling, Macia, Campbell, Hofer and King

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PLX5622 reduces leukocyte influx into WNV-infected brains. (A) tSNE plot clustered on CD45⁺ brain cells from dpi 5 PLX and Ctrl mice. (B) Stacked bar graph showing the number of brain cells in PLX and Ctrl mice at dpi 5. (C, D) Number of myeloid (C) or lymphoid (D) cells in brains of mice culled at dpi 5. (E) tSNE plot clustered on CD45⁺ brain cells from PLX and Ctrl mice at dpi 7. (F) Stacked bar graph showing the number of brain cells at dpi 7. (G, H) Number of myeloid (G) or lymphoid (H) cells at dpi 7 in brains of PLX, PLX-Ctrl and Ctrl mice. Data is presented as mean ± SEM from one (dpi 5 data) or two (dpi 7 data) independent experiments with at least three mice per group.