Figure 6.

Treatment with anti-CSF-1R, like PLX5622, reduces CNS infiltration and BM monocyte production. (A) Schematic of experimental workflow. Mice were infected with WNV and treated with an isotype control monoclonal blocking antibody or anti-CSF-1R at either 1) dpi 0, 2, 4 and 6 or 2) dpi 5 and 6. (B) Number of myeloid cells in brains of mice treated with an isotype control or anti-CSF-1R at WNV dpi 7. (C) Number of myeloid cells in infected (dpi 7) BMs from mice treated with an isotype control or anti-CSF-1R. (D, E) Number (D) and percent (E) of BrdU⁺ myeloid cells in infected (dpi 7) BMs from mice treated with an isotype control or anti-CSF-1R. Data is presented as mean ± SEM from two independent experiment with at least six mice per group.