Table 2.
Diagnostic performances of the different biomarkers for MSARD diagnosis compared to both control populations.
| MSARD vs. NIND n = 141 | MSARD vs. OIND n = 123 | |||||
|---|---|---|---|---|---|---|
| AUC (%) | 95% CI | Optimal threshold | AUC (%) | 95% CI | Optimal threshold | |
| KFLC index | 90.0a | [84.9; 95.2] | 8.4 | 82.3 | [74.6; 90.0] | 13.1 |
| KFLC IF | 88.7a | [83.0; 94.3] | 73.1 | 74.5c | [65.2; 83.8] | 82.8 |
| CSF CD25 | 59.6b | [50.1; 69.0] | 21.5 | 77.0d | [65.6; 88.5] | 41.5 |
| CSF IL-6 | 56.9b | [46.7; 67.1] | 2.0 | 87.4e | [79.8; 95.0] | 4.1 |
| CSF IL-10 | 62.7b | [56.5; 68.8] | 1.2 | 68.0 | [56.6; 79.4] | 2.4 |
CSF, cerebrospinal fluid; KFLC, kappa free light chains; MSARD, multiple sclerosis and related disorder; NIND, non-inflammatory neurological disorder; OIND, other inflammatory neurological disorder; AUC, area under the curve.
KFLC index and KFLC IF AUC are not statistically different (p = 0.404).
AUCs of CSF CD25, IL-6, and IL-10 were all lower than both KFLC biomarkers (p < 0.001 for all 6 comparisons). There was no AUC difference between CSF CD25 and CSF IL-6 (p = 0.717), CSF CD25 and CSF IL-10 (p = 0.523), and CSF IL-6 and CSF IL-10 (p = 0.314).
KFLC index and KFLC IF AUC are statistically different (p = 0.008).
CSF CD25 AUC is not statistically different than KFLC index AUC (p = 0.358), CSF IL-6 AUC (p = 0.119), or CSF IL-10 AUC (p = 0.149).
CSF IL-6 AUC is not statistically different than KFLC index AUC (p = 0.436) and CSF CD25 AUC (p = 0.119) and is higher than CSF IL-10 AUC (p = 0.007).