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. 2022 Mar 25;13:849204. doi: 10.3389/fendo.2022.849204

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Copyright © 2022 Morikawa, Blacher, Onwumere and Urano

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell apoptosis and expression of pro-inflammatory cytokine genes are upregulated in Wfs1-deficient pancreatic β-cells. (A, B) INS-1E cells were transfected with scrambled siRNA (siCont) or siRNA targeting rat Wfs1 (siWfs1). WFS1 and cleaved caspase-3 protein expression levels were analyzed by immunoblot. Representative images are shown in (A), and quantitative analysis results are shown in (B) (n=3, normalized to GAPDH). (C) mRNA expression levels of Chop, Il-1β, Il-6, and Cxcl1 (Il-8) in INS-1E cells treated with siCont or siWfs1 normalized to 18srRNA (n=5-6). Data are shown as mean ± SEM, *P < 0.05, **P < 0.005, ****P < 0.0001.