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. 2022 Mar 25;13:876043. doi: 10.3389/fmicb.2022.876043

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Copyright © 2022 Gao, Rao, Wei, Xia, Huang, Tang, Hide, Zheng, Li, Zhao, Sun and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum lipids in cynomolgus monkeys during HFD feeding. Serum levels (mmol/L) are shown for (A) total cholesterol (TC), (B) low-density lipoprotein cholesterol (LDL-C). HFD: high-fat diet monkeys; NCD: normal chow diet. Significant differences are indicated as ^#, at month 3, HFD monkeys vs NCD monkeys, p < 0.05; *, at Month 17, HFD-1/HFD-3/HFD-4 (HFD-intolerant) monkeys vs HFD-2/HFD-5 (HFD-tolerant) monkeys, p < 0.05.