Comparison 2. Rimonabant 5 mg vs placebo (after one year).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Weight [kg] change	3	2301	Mean Difference (IV, Fixed, 95% CI)	‐1.25 [‐1.64, ‐0.86]
2 Waist circumference [cm] change	3	2301	Mean Difference (IV, Fixed, 95% CI)	‐1.18 [‐1.69, ‐0.68]
3 Adverse effects (general)	3	3435	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.98, 1.04]
4 Adverse effects (serious)	4	4122	Odds Ratio (M‐H, Fixed, 95% CI)	1.29 [0.96, 1.73]
5 Systolic blood pressure [mmHg] change	3	2301	Mean Difference (IV, Fixed, 95% CI)	‐0.79 [‐1.80, 0.21]
6 Diastolic blood pressure [mmHg] change	3	2301	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.81, 0.58]
7 Triglycerides levels [mg/dl] change	3	2301	Mean Difference (IV, Fixed, 95% CI)	‐2.31 [‐8.04, 3.42]
8 High‐density lipoprotein [mg/dl] change	3	2301	Mean Difference (IV, Fixed, 95% CI)	1.26 [0.64, 1.88]
9 Discontinuation due to adverse events	4	4122	Odds Ratio (M‐H, Fixed, 95% CI)	1.21 [0.96, 1.53]