Characteristic	RIO‐Lipids	RIO‐Europe	RIO‐North America	RIO‐Diabetes
[n] adverse events (T1/ T2 / C1 / total)	407 / 367 / 340 / 1114	522 / 498 / 257 / 1277	1042 / 1013 / 498 / 2553	288 / 293 / 276 / 857
[%] adverse events (T1/ T2 / C1 / total)	117.6 / 106.4 / 99.4 / 107.8	87.1 / 82.6 / 84.3 / 84.7	85.5 / 83.4 / 82.0 / 84.0	85 / 81.8 / 79.3 / 82
[n] nausea (T1/ T2 / C1 / total)	44/ 25 / 11 / 80	77 / 31 / 13 / 121	117 / 69 / 29 / 215	41 / 22 / 20 / 83
[%] nausea (T1/ T2 / C1 / total)	12.7 / 7.2 / 3.2 / 7.7	12.9 / 5.1 / 4.3 / 8.0	11.2 / 6.8 / 5.8 / 7.1	12.1 / 6.1 / 5.7 / 7.9
[n] dizziness (T1/ T2 / C1 / total)	36 / 29 / 23 / 88	52 / 42 / 15 / 109	58 / 46 / 20 / 114	31 / 11 / 17 / 59
[%] dizziness (T1/ T2 / C1 / total)	10.4 / 8.4 / 6.7 / 8.5	8.7 / 7.0 / 4.9 / 7.2	5.6 / 4.5 / 4.0 / 4.1	9.1 / 3.1 / 4.9 / 5.6
[n] serious adverse events (T1/ T2 / C1 / total)	15 / 19 / 10 / 44	52 / 45 / 23 / 120	55 / 46 / 21 / 122	27 / 27 / 15 / 69
[%] serious adverse events (T1/ T2 / C1 / total)	4.3 / 5.5 / 2.9 / 4.3	8.7 / 7.5 / 7.5 / 8.0	4.5 / 3.8 / 3.5 / 4.0	8.0 / 7.5 / 4.3 / 6.6
[n] psychiatric disorders (T1/ T2 / C1 / total)	1/ 1 / 1 / 3	9 / 2 / 1 / 12	76 / 44 / 14 / 134	?
[%] psychiatric disorders (T1/ T2 / C1 / total)	0.3 / 0.3 / 0.3 / 0.3	1.5 / 0.3 / 0.3 / 0.8	6.2 / 3.6 / 2.3 / 4.4	?
[n] nervous system disorders (T1/ T2 / C1 / total)	2 / 0 / 2 / 4	3 / 7 / 3 / 13	27 / 14 / 6 / 47	?
[%] nervous system disorders (T1/ T2 / C1 / total)	0.6 / 0 / 0.6 / 0.4	0.5 / 1.2 / 1.0 / 0.9	2.2 / 1.2 / 1.0 / 1.6	?
[n] neoplasms (T1/ T2 / C1 / total)	2 / 3 / 0 / 5	7 / 5 / 2 / 14	?	?
[%] neoplasms (T1/ T2 / C1 / total)	0.6 / 0.9 / 0 / 0.5	1.2 / 0.8 / 0.7 / 0.9	?	?
[n] discontinuation due to adverse events (T1/ T2 / C1 / total)	52 / 29 / 24 / 105	87 / 50 / 28 / 165	156 / 114 / 44 / 314	51 / 28 / 19 / 98
[%] discontinuation due to adverse events (T1/ T2 / C1 / total)	15.0 / 8.4 / 7.0 / 10.2	14.5 / 8.3 / 9.2 / 10.9	12.8 / 9.4 / 7.2 / 10.3	15.0 / 7.8 / 5.5 / 9.4
[n] hospitalisation (T1/ T2 / C1 / total)	?	?	?	?
[%] hospitalisation (T1/ T2 / C1 / total)	?	?	?	?
[n] out‐patient treatment (T1/ T2 / C1 / total)	NA	NA	NA	NA
[%] out‐patient treatment (T1/ T2 / C1 / total)	NA	NA	NA	NA
[n] hypoglycaemic episodes (T1/ T2 / C1 / total)	NA	NA	NA	NA
[%] hypoglycaemic episodes (T1/ T2 / C1 / total)	NA	NA	NA	NA
[n] severe hypoglycaemic episodes (T1/ T2 / C1 / total)	NA	NA	NA	NA
[%] severe hypoglycaemic episodes (T1/ T2 / C1 / total)	NA	NA	NA	NA
[n] nocturnal hypoglycaemic episodes (T1/ T2 / C1 / total)	NA	NA	NA	NA
[%] nocturnal hypoglycaemic episodes (T1/ T2 / C1 / total)	NA	NA	NA	NA
[n] with symptoms (T1/ T2 / C1 / total)	NA	NA	NA	NA
[%] with symptoms (T1/ T2 / C1 / total)	NA	NA	NA	NA
Notes
Symbols: unclear=?
Abbreviations: T=treatment, C=control, NA=not applied