Characteristic	RIO‐Lipids	RIO‐Europe	RIO‐North America	RIO‐Diabetes
Total cholesterol / HDL ratio change [mean,SD] (T1/ T2 / C1 / total)	T1 ‐0.72 (0.93) T2 ‐0.47 (0.82) C ‐0.40 (0.90)	T1 ‐0.71 (0.78) T2 ‐0.52 (0.80) C ‐0.42 (0.83)	?	?
Triglycerides change [mean,SD] (T1/ T2 / C1 / total)	T1 ‐12.6 (41.2) T2 +1.2 (39.4) C ‐0.2 (38.7)	T1 ‐0.20 (0.64) T2 ‐0.02 (0.77) C ‐0.20 (0.64)	T1 ‐5.3 (?) T2 ‐3.7 (?) C +7.9 (?)	T1 ‐31.0 (113.0) T2 ‐1.0 (70.0) C +4.0 (77.0)
HDL change [mean,SD] (T1/ T2 / C1 / total)	T1 +19.1 (20.9) T2 +14.2 (17.6) C +11.0 (15.8)	T1 +0.26 (0.26) T2 +0.19 (0.23) C +0.15 (0.23)	T1 +12.6 (?) T2 +7.6 (?) C +5.4 (?)	T1 +6.0 (8.0) T2 +4.0 (7.0) C +3.0 (6.0)
LDL change [mean,SD] (T1/ T2 / C1 / total)	T1 +7.2 (28.4) T2 +6.6 (21.4) C +7.0 (22.4)	T1 +0.08 (0.63) T2 +0.13 (0.62) C +0.17 (0.70)	?	?
Blood pressure systolic change [mean,SD] (T1/ T2 / C1 / total)	T1 ‐2.1 (12.3) T2 ‐0.4 (11.8) C ‐0.3 (10.1)	T1 ‐1.0 (12.5) T2 ‐0.9 (12.5) C ‐0.3 (12.3)	?	T1 ‐0.8 (12.8) T2 ‐0.4 (12.9) C +1.6 (13.2)
Blood pressure diastolic change [mean,SD] (T1/ T2 / C1 / total)	T1 ‐1.7 (8.5) T2 ‐0.1 (8.3) C ‐0.2 (7.4)	T1 ‐0.9 (8.7) T2 ‐0.8 (8.8) C ‐0.1 (8.5)	?	T1 ‐1.9 (8.2) T2 ‐0.4 (8.5) C ‐0.7 (8.4)
Notes	results by last observation carried forward	results by last observation carried forward	results by last observation carried forward results published as placebo subtract changes from baseline for 1 year, this results were obtained from results published in American Hearth Association 2004 Scientific Sessions ‐ http://www.medscape.com/viewarticle/493901	results by last observation carried forward
Symbols: unclear=?
Abbreviations: T=treatment; C=control