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Schematic diagram of the immunosuppressive effect of radiotherapy (RT) with associated exosomes. Tumor cells and immune cells in acquired and congenital pathways are capable of releasing or receiving exosomes generated by RT to adjust the immune system into a depressed state. Exosomal MHC Ⅰ, miR‐590‐3p, SIRPα, and miR‐378a‐3p are increased in association with innate immunity. Exosomal PD‐L1, B7‐H3, TIGIT, TIM‐3, and LAG‐3 levels are increased in association with adaptive immunity
