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Genetic landscape of the mutational hotspot at chromosome Xq27.1. Diagram depicts the RefSeq curated genes located within ∼3 Mb on either side of the quasi-palindrome sequence, which acts as a hotspot for genomic rearrangements. The quasi-palindrome is situated within a ∼410 kb gene desert (red box), with 82 kb of non-coding sequence separating it from the closest coding gene (SOX3). Image created with BioRender.com using information obtained from UCSC Genome Browser (GRCh38/hg38).
