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. 2022 Mar;11(3):475–487. doi: 10.21037/tcr-21-2903

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2022 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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LncRNA01977 acts as a molecular sponge by binding to SDF-1. (A,B) Subcellular localization of LncRNA01977, Actin: cytoplasmic positive control; U6: nucleus positive control. (C) Left panel: real-time PCR analysis of LncRNA01977 and SDF-1 enriched with AGO2 protein in HCC-78, KTA-7 and PC-9 cells. Right panel: protein blotting was used to confirm the specific immunoprecipitation of Ago2. (D,E) Real-time PCR confirmed the interactions between LncRNA01977 and SDF-1 in HCC-78, KTA-7 and PC-9 cells. (F) A schematic representation of the wild-type LncRNA01977 luciferase reporter vector. (G) Double-luciferase gene activity detection. *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001; +, positive; −, negative; ns, meaningless. LUAD, lung adenocarcinoma; DOX, Docetaxel; TCGA, The Cancer Genome Atlas; NC, normal contras; PCR, polymerase chain reaction.