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Honeysuckle and APS-L inhibit SARS-CoV2 Mpro activity. (A) Activity of SARS-CoV-2 Mpro in the presence of a peptide substrate, a fluorogenic probe (Abz-TSAVLQSGFRK-Dnp). The concentrations of the peptide substrate varied from 2 to 40 µM in PBS buffer, while Mpro concentration was fixed at 0.12 µM. The effect of honeysuckle-EtOH (B) and APS-L (C) on SARS-CoV-2 Mpro activity was investigated. The IC50 value for each reaction was calculated and displayed.
