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. 2022 Mar 25;13:869162. doi: 10.3389/fphar.2022.869162

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Copyright © 2022 Serhal, Armour, Billot, Krass, Emmerton, Saini, Bosnic-Anticevich, Bereznicki, Bereznicki, Shan and Campain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of differences in Proportion of Days Covered estimates between claims records alone and combined claims records and pharmacy dispensing data. Negative values indicate a lower PDC when patients prescribed dose is included in the analysis instead of the standard dose assumption. The differences between the PDC estimates based on patients prescribed dose versus the standard dose assumption have a skewed distribution. Therefore, it is likely that greater dose variability amongst some asthma patients within the cohort may have contributed to this finding.