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. 2022 Mar 25;13:833545. doi: 10.3389/fgene.2022.833545

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Copyright © 2022 Wu, Wei, Fan, Gu, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ceRNA interaction and protein-protein interaction analysis. (A) ceRNA network diagram. In the network diagram, red indicates upregulation, blue indicates downregulation, squares indicate lncRNA, triangles indicate miRNA, and circles indicate mRNA. Sankey diagram (B). The three columns include lncRNAs, miRNAs, and mRNAs in order from left to right. The line colors represent different types of gene-gene interactions. (C) Diagram of interaction of differentially expressed proteins. Red indicates increased expression, blue indicates decreased expression, and color intensity indicates different degrees of u-regulation or downregulation. Orange represents the hub genes. (D) Diagram of hub-genes interaction in differentially expressed proteins. (E) MiRNAs targeting mRNAs interaction diagram. Red indicates upregulated expression, blue indicates downregulated expression, and color intensity indicates different degrees of upregulation or downregulation. Orange represents hub genes. (F) Diagram of hub genes interaction in targeted mRNAs.