Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 25;13:820806. doi: 10.3389/fphar.2022.820806

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Fuloria, Mehta, Chandel, Sekar, Rani, Begum, Subramaniyan, Chidambaram, Thangavelu, Nordin, Wu, Sathasivam, Lum, Meenakshi, Kumarasamy, Azad and Fuloria.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mechanism of curcumin in regulation of cancer proliferation. TGF-β1/smad3, IGF, PI3K/Akt, Wnt/β-catenin, and vascular endothelial growth factor (VEGF) are some of the signaling pathways and molecular targets that curcumin modulates to inhibit cancer. Blocking these receptors has the potential to reduce chronic inflammation and oxidative damage. DSH and AXIN are recruited once the WNT binds to LRP 5/6, producing the β-catenin destruction complex. β-catenin that has escaped into the nucleus promotes the transcription of genes including cyclin D1 and P13k, which promote cell proliferation and growth. IGF-1R, Insulin-like growth factor 1 receptor; TGF-β1, Transforming growth factor beta 1; WNT, Wingless/integrated; LRP 5/6, Low-density lipoprotein receptor-related protein 5/6; Smad, small mothers against decapentaplegic; Ras, Rat sarcoma virus; Raf, Rapidly Accelerated Fibrosarcoma; MEK 1/2, Mitogen-activated protein kinase 1/2; ERK ½, Extracellular-signal-regulated kinase ½; P13K, Phosphoinositide 3-kinases; Akt, Ak strain transforming; mTOR, mammalian target of rapamycin; TCF/LEF, T-cell factor/lymphoid enhancer factor; FZD, Frizzled; DSH, Dishevelled; AXIN, Axis Inhibitor; APC, Adenomatous polyposis coli; GSK-3β, Glycogen synthase kinase-3 beta; CK-1, casein kinase 1.