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. 2022 Mar 25;9:742193. doi: 10.3389/fcvm.2022.742193

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Copyright © 2022 Agostinucci, Grant, Seelig, Yücel, van Berlo, Bartolomucci, Dyck and Zordoky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ANGII, but not ISO, exacerbates the upregulation of inflammatory and fibrotic markers in DOX-exposed mice. Male 5-week old mice were administered DOX (4 mg/kg/week) or saline for 3 weeks and allowed to recover for 5 weeks prior to exposure to (A–C) ANGII (1.4 mg/kg/day for 14 days) or (D–F) ISO (10 mg/kg/day for 14 days). The mRNA expression of (A,D) the inflammatory marker Cox-2, and the fibrotic markers (B,E) Col1a1 and (C,F) Col3a1 was determined by real-time PCR (n = 5-6 per group). Results were normalized to beta-actin and are expressed relative to the control group. Statistical significance of pairwise comparisons was determined by two-way ANOVA with Tukey's post-hoc analysis (^*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). ANGII, Angiotensin II; DOX, doxorubicin; ISO, isoproterenol.