Figure 8.

Divergent cardiac effects of ANGII and ISO in adult mice pre-exposed to DOX as juveniles. Male 5-week old mice were administered DOX (4 mg/kg/week) or saline for 3 weeks and allowed to recover for 5 weeks prior to exposure to ANGII (1.4 mg/kg/day for 14 days) or ISO (10 mg/kg/day for 14 days). Juvenile exposure to DOX prevented both ANGII- and ISO-induced cardiac hypertrophy, but failed to correct the upregulation in hypertrophic markers. ANGII, but not ISO, worsened cardiac function, exacerbated cardiac fibrosis, and upregulated inflammatory and fibrotic markers in DOX-exposed mice. ANGII, Angiotensin II; DOX, doxorubicin; ISO, isoproterenol.