TABLE 2.

Compound mutant mouse models with enamel defects.

#	Gene Symbol	Gene Name	Location	Enamel Phenotype	Mouse Strain	PMID
1	Ambn and Enam	ameloblastin and enamelin	5 E1 and 5 E1	hypoplastic	Ambn +/- ;Enam +/-	31478359
2	Bmp2 and Bmp4	bone morphogenetic protein 2 & bone morphogenetic protein 4	2 F2 and 14 C4	hypomineralized	K14-Cre;Bmp2 F/F ;Bmp4 F / F	27146352
3	Klk4 and Mmp20	kallikrein related-peptidase 4 and matrix metallopeptidase 20	7 B3 and 9 A1	hypoplastic and hypomineralized	Klk4 −/− ;Mmp20 −/−	27066511
4	Stim1 and Stim2	stromal interaction molecule 1 and stromal interaction molecule 2	7 E2-E3 and 5 C1	hypomineralized	K14-Cre;Stim1 F/F ;Stim2 F/F	28732182