TABLE 3.

Classification of enamel defects.

Phenotype	Gene Symbols
hypoplastic/no enamel/chalky-white	Alpl, Ambn, Amelx, Arhgap6, Ascl5, Cldn16, Csf1, Dmp1, Dspp, Eda, Enam, Fam20a, Fam20c, Fam83h, Fgfr1, Gdnf, Gja1, Hmgn2, Itgb1, Irf6, Lama3, Ltbp3, Mmp20, Msx2, Pax9, Plau, Postn, Rac1, Rhoa, Runx1, Slc4a4, Slc13a5, Sp3, Sp6, Stim1, Tbx1, Tgfb1, Tgfbr2, Ambn and Enam, Klk4 & Mmp20
hypomaturation	Amtn, Col17a1, Enam, Foxo1, Slc10a7, Wdr72
hypomineralized/hypocalcified	Amelx, Amtn, Bcl11b, Bmp2, Cftr, Cldn3, Cldn16, Cnnm4, Col17a1, Ctnnb1, Dlx3, Dmp1, Fam20a, Fam20c, Hras, Itgb6, Klk4, Lamc2, Map3k7, Med1, Mmp20, Nectin1, Rac1, Relt, Runx2, Smad3, Slc4a4, Slc10a7, Slc12a2, Slc24a4, Stim1, Tcirg1, Tgfb1, Tgfbr2, Tmbim6, Wdr72, Bmp2 & Bmp4, Klk4 & Mmp20, Stim1 & Stim2
unknown	Lamb3, Nectin3, Pitx2, Sp7