TABLE 4.

Functional category of amelogenesis imperfecta-related genes.

Category Name	Gene Symbols
Extracellular matrix	Ambn, Amelx, Amtn, Col17a1, Csf1, Dmp1, Dspp, Enam, Lama3, Lamb3, Lamc2, Postn
Enzyme	Alpl, Fam20a, Fam20c, Hras, Klk4, Map3k7, Mmp20, Plau, Rac1, Rhoa, Tcirg1
Receptor	Fgfr1, Itgb1, Itgb6, Relt, Tgfbr2
Receptor binding molecule	Ltbp3
Ion exchanger or transporter	Cftr, Cnnm4, Slc4a4, Slc10a7, Slc12a2, Slc13a5, Slc24a4
Calcium sensor or regulator	Stim1, Stim2, Tmbim6
Cell-cell or cell-ECM adhesion molecule	Cldn3, Cldn16, Ctnnb1, Gja1, Nectin1, Nectin3
Growth factor	Bmp2, Bmp4, Gdnf, Tgfb1
Transcriptional factor	Ascl5, Bcl11b, Ctnnb1, Dlx3, Foxo1, Irf6, Msx2, Pax9, Pitx2, Runx1, Runx2, Sp3, Sp6, Sp7, Tbx1
Transcriptional regulator	Hmgn2, Med1
Signal mediator	Smad3
Unknown	Fam83h, Wrd72