TABLE 6.
MicroRNA (miRNA) enrichment analysis of mouse genes related to amelogenesis imperfecta.
| miR ID | Target Genes | # Targets | Adjusted p-value | FDR |
|---|---|---|---|---|
| miR-16-5p | Bcl11b, Csf1, Eda, Fgfr1, Med1, Relt, Slc4a4, Slc10a7, Slc12a2, Smad3, Stim1, Stim2 | 12 | 3.94 × 10–7 | 1.63 × 10–3 |
| miR-27b-3p | Bmp2, Csf1, Foxo1, Pax9, Runx1, Slc10a7, Slc24a4, Smad3, Sp6, Sp7, Stim2, Tmbim6 | 12 | 4.12 × 10–7 | 1.69 × 10–3 |
| miR-23a/b-3p | Bcl11b, Cldn16, Gja1, Hmgn2, Pax9, Runx2, Slc4a4, Slc12a2, Smad3, Tgfbr2 | 10 | 8.51 × 10–6 | 2.01 × 10–3 |
| miR-214-3p | Csf1, Ctnnb1, Fgfr1, Irf6, Sp7, Stim2 | 6 | 9.38 × 10–5 | 1.43 × 10–3 |
| miR-30b/c-5p | Bcl11b, Csf1, Eda, Gdnf, Gja1, Pax9, Runx1, Runx2, Stim2 | 9 | 3.82 × 10–4 | 4.49 × 10–3 |
| miR-125a/b-5p | Fam20a, Fam83h, Gdnf, Gja1, Pax9, Slc4a4, Stim1 | 7 | 7.57 × 10–4 | 7.86 × 10–3 |
| let-7a/f-1-3p | Cftr, Ctnnb1, Foxo1, Rhoa | 4 | 9.98 × 10–4 | 9.85 × 10–3 |
| let-7b-3p | Cftr, Ctnnb1, Foxo1, Rhoa | 4 | 9.98 × 10–4 | 9.85 × 10–3 |
| let-7c-2-3p | Cftr, Ctnnb1, Foxo1, Rhoa | 4 | 9.98 × 10–4 | 9.85 × 10–3 |
| miR-181b-5p | Lama3, Pax9, Plau, Pitx2, Runx1, Stim2, Tgfb1 | 7 | 3.03 × 10–3 | 2.45 × 10–2 |
| miR-206-3p | Alpl, Csf1, Gja1, Med1, Slc10a7 | 5 | 8.07 × 10–3 | 5.53 × 10–2 |
| let-7c-1-3p | Gdnf, Runx2 | 2 | 1.29 × 10–2 | 8.20 × 10–2 |
| let-7b-5p | Cnnm4, Dmp1, Eda, Slc4a4, Slc10a7, Stim1 | 6 | 1.77 × 10–2 | 1.07 × 10–1 |
| miR-199a-3p | Gja1, Runx1, Stim2 | 3 | 3.40 × 10–2 | 1.89 × 10–1 |
| let-7a/c/d/e/f/g/i-5p | Cnnm4, Dmp1, Eda, Slc4a4, Slc10a7 | 5 | 3.43 × 10–2 | 1.90 × 10–1 |
| miR-214-5p | Csf1, Slc13a5 | 2 | 3.92 × 10–2 | 2.14 × 10–1 |
| miR-26a-5p | Itgb1, Pitx2, Slc4a4, Slc12a2, Slc24a4 | 5 | 4.91 × 10–2 | 2.62 × 10–1 |
Adjusted p-value < 0.05 was used as the cutoff threshold. FDR: false discovery rate. miRNAs sharing the same target genes and with the same adjusted p-value were merged (e.g., miR-23a/b-3p).