TABLE 3.
Estimates of RRs and the 95% CIs for adverse cardiovascular disease and heterogeneity test for studies with Cochran’s Q-test and the quantity I2.
| Type | No. of data sets | No. of cases | No. of controls | RR | 95% CI | Q-value | I2(%) | P-value |
| Cadiovascular outcome | ||||||||
| Myocardial infarction | 13 | 522,730 | 11,171,909 | 1.17*** | 1.11–1.24 | 19.94 | 40 | < 0.00001 |
| Stroke | 10 | 484,839 | 11,529,624 | 1.19*** | 1.11–1.27 | 23.00 | 61 | < 0.00001 |
| Cardiovascular death | 5 | 183,966 | 4116,176 | 1.46*** | 1.26–1.69 | 7.27 | 45 | < 0.00001 |
| Ischemic heart disease | 3 | 67,048 | 2,129,260 | 1.17* | 1.02–1.34 | 5.65 | 65 | 0.03 |
| Thromboembolism | 4 | 63,236 | 4,971,594 | 1.36*** | 1.20–1.55 | 6.03 | 50 | < 0.00001 |
| Arrhythmia | 3 | 93,580 | 5,380,933 | 1.35*** | 1.30–1.40 | 1.67 | 0 | < 0.00001 |
| Others | 8 | 330,342 | 17,942,545 | / | / | / | / | / |
| Ethnic origin | ||||||||
| Asian | 7 | 110,591 | 2,813,658 | 1.35*** | 1.22–1.50 | 20.98 | 71 | < 0.00001 |
| European | 24 | 554,418 | 15,089,099 | 1.22*** | 1.18–1.27 | 64.75 | 64 | < 0.00001 |
| Severity of psoriasis | ||||||||
| Mild | 18 | 857,939 | 39,811,954 | 1.18*** | 1.13–1.24 | 100.75 | 83 | < 0.00001 |
| Moderate and severe | 22 | 917,271 | 400,631,311 | 1.41*** | 1.31–1.52 | 78.75 | 73 | < 0.00001 |
*P < 0.05, ***P < 0.0001.