TABLE 2.

In vitro susceptibilities of C. neoformans to fluconazole and details of treatments and clinical outcomes for 25 patients

Patient no.	Fluconazole MIC (μg/ml)	Antifungal therapya	Outcome of therapy
1	0.25	A + FL for 38 days and then FZ at 400 mg day on discharge (day 44)	Cure
2	0.5	A + FL for 7 days, then FZ at 400 mg/day for 7 days and then FZ at 400 mg on discharge	Cure
3	1	A + FL for 4 wk and then on day 7 FZ at 200 mg/day on discharge	Cure
4	1	A + FL for 7 days and then on day 7 FZ at 400 mg intravenously	Died on day 11
5	1	A for 29 days and then FZ at 400 mg/day on discharge	Cure
6	1	A + FL for 24 h and then FZ at 400 mg/day	Died on day 3
7	2	A for 10 days and then on day 10 FZ at 400 mg/day	Cure
8	2 & 4b	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
9	4	A until a total dose of 1 g and then FZ at 400 mg/daya	Cure
10	4	A + FL for 8 days and then FZ at 400 mg/day on discharge	Cure
11	4	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
12	4	A + FL for 19 days and then FZ at 400 mg/day	Cure
13	4	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
14	4	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
15	4 & 8b	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
16	4 & 8b	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
17	8	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
18	8	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
19	8	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
20	8	A until a total dose of 1 g and then FZ at 400 mg/dayc	Cure
21	16	A until a total dose of 1 g and then FZ at 400 mg/dayc	Failure (died, day 9)
22d	32	A until a total dose of 1 g and then FZ at 400 mg/day	Failure
23	8→32e	A until a total dose of 1 g and then FZ at 400 mg/dayc	Failure (died, wk 6)
24	8→64e	A until a total dose of 1 g and then FZ at 400 mg/dayc	Failure (died, wk 10)
25	4→64e	A until a total dose of 1 g and then FZ at 400 mg/dayc	Failure (died, wk 5)

^aA, amphotericin B; FL, flucytosine; FZ, fluconazole. 

^bMICs for isolates from blood and CSF, respectively. 

^cPatients were treated until the total dose of amphotericin B was achieved; treatment with fluconazole at 400 mg/day was continued for 8 to 10 weeks, and then the patient was maintained on fluconazole at 200 mg/day p.o. 

^dCurrently treated with itraconazole (600 mg/day p.o.). 

^eFluconazole MIC for initial and relapse isolates, respectively.