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. 2022 Mar 24;144(13):5956–5964. doi: 10.1021/jacs.2c00178

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© 2022 The Authors. Published by American Chemical Society

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Replication assays. Representative time-dependent denaturing PAGE analyses following the replication of the noncanonical structures formed by (a) (T₂AG₃)₄ or (b) (G₃T₂A)₂G₃T₃G₃ template strands with and without the presence of the enantiomerically pure ligands. Replication experiments were conducted with 10 mM KCl at pH 6.5 (see Supporting Information section S1.5 for complete experimental details). (c) Kinetic analysis of the time-course of each experiment showing a comparison of each ligand by its ability to stall the replication of the given template sequence. The error bars shown are calculated as the s.d. of triplicate experiments (see Figures S10 and S11 for triplicates and SYBR-stained gels). Calculated rate constants for all the systems investigated can be found in Table S5.