Skip to main content
. 2022 Mar 24;144(13):5956–5964. doi: 10.1021/jacs.2c00178

Figure 7.

Figure 7

NMR structural comparisons. Structures obtained via NMR studies of ligand binding to G-quadruplexes that exhibit comparative structural features or ligand–DNA interactions. (a) Epiberberine bound to the hybrid-2 form of htelo26, highlighting the pseudo-intercalation between a terminal G-tetrad and the nucleobases in the second loop. (b) ΛΛ-[{Ru(bpy)2}2(tpphz)]2+ bound via a loop-threading mode to the antiparallel form of htelo22. The complex binds with diastereoselectivity and exhibits complex–nucleobase interactions that are enantiospecific to the lambda isomer (inset), similar to what is observed in the reported structure. (c) Au-oxo6 bound to the hybrid-2 form of htelo26, (TTAGGG)4TT. This structure shows the gold complex neatly end-capping a terminal G-tetrad, but also interacting via π-stacking with an adenine in the flanking region.